Working together with the Substance Abuse and Mental Health Administration's (SAMHSA) Strategic Prevention Framework, the Mayahuel Prevention Consortium (MPC) prevents substance misuse among vulnerable populations while fortifying community and state-level prevention infrastructures. The MPC delineates its objectives as follows: targeted prevention, community education, strengthens infrastructure, resource mobilization, evidence-based intervention, and capacity building. The MPC adopts a community-centered approach, that integrates evidence-based strategies and community-defined best practices which address the complex and multifaceted issues surrounding alcohol/underage drinking, marijuana, and opioid misuse within the youth and young adult populations.